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677 | P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 2(6): November-December 2013 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY AND BIO SCIENCES IMPACT FACTOR 1.89*** ICV 5.13*** Pharmaceutical Sciences RESEARCH ARTICLE……!!! FORMULATION AND EVALUTION OF MOUTH DISSOLVING TABLETS OF METOCLOPRAMIDE HYDROCHLORIDE BY DIRECT COMPRESSION TECHNIQUE. Snehalatha *, B.Shivakumar, Krs Sambhashiva Rao, P.Sudhaker, Dept. Of Biotechnology,Acharya nagarjuna University, Nagarjun Nagar,Guntur. ABSTRACT KEYWORDS: Fast dissolving drug delivery system offers a solution for those patients having difficulty in swallowing tablet. In the present Fast-dissolving tablets, study, an attempt has been made to prepare fast dissolving Metoclopramide tablets of the drug Metoclopramide hydrochloride using Hydrochloride, superdisintegrants Crospovidone, Croscarmellose sodium and Superdisintegrants. Sodium starch glycolate by direct compression technique. The For Correspondence: prepared tablets were evaluated for hardness, friability, wetting Snehalatha * time, weight variation, in vitro disintegration time and in Address: vitrodissolution study. The hardness of the tablets was in the Dept. of Biotechnology, range of 2.0 - 4.0 Kg/cm². The percentage fr iability of the Acharya Nagarjuna tablets was less than one. Weight variation test results showed University, Nagarjun that the tablets were deviating from the average weight within Nagar,Guntur. the permissible limits of ±7.5 %. Drug content uniformity study results showed that uniform dispersion of the drug throughout the formulation i.e. 98.54% to 101.23%. Tablets containing Crospovidone showed better disintegrating character along with the rapid release (97.42% drug within 1 minute). Full Text Available On www.ijupbs.com 678 | P a g e International Standard Serial Number (ISSN): 2319-8141 INTRODUCTION: Solid dosage forms and capsules are most popular and preferred drug delivery system because of they have a high patient compliance. Many patient find difficulty to swallow tablet and hard gelatin capsule, consequently they do not take medication as prescribed. It is estimated that 50% of the population is affected by this problem which result high incidence of non- compliance and ineffective therapy [1]. The difficulty is experienced in particular by pediatric and geriatric patients, but it is applicable to people who are ill in bed and those active working patients who are busy or traveling, mentally ill, developmentally disable and patients who are uncooperative. To overcome this problem fast dissolving tablet is prepared. Metoclopramide HCl stimulates motility of the upper GI without stimulating gastric, pancreatic or biliary secretions which shows the metoclopramide HCl acts as an anti-emetic. With the view to all the above information, an attempt had been made to develop a rapidly disintegrating Metoclopramide HCl mouth dissolving tablets of which disintegrate in the oral cavity without the need of water within a matter of seconds. This will lead to the formation of suspension / solution form which can be easily swallowed, thereby improving dissolution rate and bioavailability of drug and onset of pharmacological action. Materials and Methods Materials Metoclopramide HCl, Crospovidone, aspartame, Mannitol and Magnesium stearate were procured/gifted from Stallions laboratories pvt. Ltd., kerala G.I.D.C., Bawla, Gujarat , India, were used and all other chemicals /solvents used were analytical grade. Methodology Method Formulation of mouth dissolving tablets of Metoclopramide Hydrochloride: Tablet each containing 5 mg Metoclopramide Hydrochloride were prepared as per composition given in Table1. The drug and excipients were passed through sieve (#60) to ensure the better mixing. Mannitol was used as a direct compressible vehicle. Superdisintigrant like Crospovidone was used in different ratios. The powder was compressed using Rimek compression machine equipped with 8 mm round punch by direct compression technique. A minimum of 100 tablets was

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